Proton Therapy For Lymphoma
Fight Lymphoma with Laser-Like Precision
California Protons’ intensity-modulated pencil beam radiation therapy technology is a highly precise form of cancer radiation treatment that enables our doctors to selectively target tissues within the lymphatic system affected by tumor cells.
Compared with older passive-scattering proton therapy treatment, our pencil beam scanning technology precisely delivers radiation treatment for lymphoma within 2 millimeters and with the utmost care. We can attack tumors layer by layer and minimize harmful exposure to surrounding healthy tissue and organs. This is important when treating lymphomas near vital organs that are sensitive to the combined effects of chemotherapy and radiation. The reduction of radiation-related toxicity also increases the likelihood that patients can complete treatment with fewer interruptions or delays.
What is Proton Therapy for Lymphoma?
Proton therapy is an advanced form of radiation treatment that uses protons — positively charged particles — to target cancer cells with pinpoint accuracy. Unlike conventional X-ray radiation, which passes through the body and can damage healthy organs, protons can be controlled to stop precisely at the tumor. This allows doctors to deliver high doses of radiation to the lymphoma while reducing unnecessary exposure to the heart, lungs, breasts, and other sensitive tissues.
For lymphoma patients, this precision is especially valuable. Lymphomas often develop in or near the chest, neck, and abdomen, where vital organs are at risk. By protecting these healthy structures, proton therapy helps patients tolerate treatment better, lowers the risk of long-term complications, and improves overall quality of life.
Lymphoma
Treatment Details
What We Treat
- Hodgkin’s disease
- Non-Hodgkin’s lymphoma
- Plasmacytoma (multiple myeloma)
- Recurrent cancer
What We Do
- Target the tumor only
- Protect your heart, lungs, breasts and other nearby organs
- Maintain your quality of life during treatment
- Reduce side effects of treatment, including nausea, vomiting and fatigue
- Lower the risk of secondary cancer due to radiation
Who is a Candidate for Proton Therapy for Lymphoma?
Not all lymphoma patients require proton therapy, but for many, it offers clear advantages over traditional radiation.
- Hodgkin’s lymphoma in the chest: Proton therapy can minimize radiation exposure to the heart and lungs, reducing risks of cardiovascular disease and lung damage later in life.
- Recurrent lymphoma:Patients who previously received radiation may benefit from proton therapy’s ability to safely re-treat areas with minimal risk to surrounding healthy tissue.
- Younger patients: Because children and young adults are more sensitive to radiation, proton therapy helps protect their developing bodies from long-term side effects and secondary cancers.
- Lymphomas near critical organs: When tumors are close to sensitive structures such as the breasts or spinal cord, proton therapy provides precision that other treatments cannot match.
Ultimately, whether proton therapy is the right choice depends on the type of lymphoma, its stage, your age, overall health, and prior treatments. At California Protons, each patient receives an individualized evaluation to determine the safest and most effective plan.
Benefits of Proton Therapy for Lymphoma

- Our pencil beam scanning technology precisely controls protons to place the Bragg peak—the point at which they deposit their maximum energy—directly in the tumor. This allows us to treat more complex tumor shapes and vary the dose within the tumor.
- Advanced proton therapy allows doctors to more selectively deliver high-dose radiation to cancerous tumors and tissues in the lymphatic system, and reduce the dose to surrounding healthy tissues and critical organs. In some cases, this has been shown to deliver higher cure rates than X-ray radiation treatment even in some of the most challenging situations.
- Proton beam therapy deposits the maximum energy directly in the tumor, which can spare healthy tissues around the tumor and reduce radiation exposure to surrounding organs.
- Lymphoma patients receiving proton therapy may experience fewer or less severe radiation side effects and are at reduced risk of developing secondary cancers to breasts, lungs and other organs later in life.
- Unlike with older technology, the lymphoma treatment plan can be loaded into the computer and completed within a matter of minutes. Treatments are also noninvasive and convenient so patients can get back to their daily activities quicker.
Key Benefits for Lymphoma Patients
Some key benefits of proton therapy for lymphoma patients include the following:
- Protecting vital organs: Proton therapy limits radiation exposure to the heart, lungs, breasts, and other nearby tissues.
- Fewer side effects: Patients often report less fatigue, nausea, and skin irritation compared to standard radiation.
- Reduced long-term risks: Lower radiation exposure means a decreased chance of secondary cancers developing years after treatment.
- Safer retreatment option: For patients who had radiation before, proton therapy provides a safer way to receive additional treatment.
- Better quality of life during treatment: Many patients are able to continue their daily activities, work, and exercise routines while undergoing proton therapy.
What to Expect During Proton Therapy
Many patients feel anxious about starting treatment because they don’t know what to expect. Proton therapy is noninvasive, painless, and usually very well tolerated. Here’s what the process looks like:
- Consultation & Planning: Patients meet with our radiation oncologists, who review medical history, imaging scans, and prior treatments to design a customized plan.
- Simulation & Imaging: Advanced CT or MRI scans help map the exact shape and size of the tumor, ensuring precise targeting.
- Daily Treatment Sessions: Most patients receive therapy 5 days a week for 4–6 weeks. Each session lasts about 30–45 minutes, though the actual proton delivery only takes a few minutes.
- Recovery & Follow-Up: Proton therapy has fewer interruptions, meaning patients are more likely to complete their treatment schedule. After treatment, patients return for routine scans to monitor progress.
Is Proton Therapy
For Lymphoma
Right for You?
Depending on the stage, proton therapy for lymphoma can be a treatment option in place of standard X-ray radiation and chemotherapy or can be delivered in combination with chemotherapy. Treatment options are also affected by the type of lymphoma, age, overall health and personal preferences.
Treatment for
Recurrent Lymphoma Cancer
Proton therapy is often the best way to treat recurrent tumors in areas that have previously been treated with radiation therapy.
Treating previously irradiated areas can be challenging. The healthy tissues around the recurrent tumor do not fully “forget” the previous radiation dose, and any added dose continues to increase the risk of normal tissue injury. Proton beam therapy for lymphoma may enable doctors to better concentrate the dose to the target and limit it elsewhere, allowing re-treatment with radiation in select patients.
Proton Therapy Treatment for Lymphoma Outcomes & Long-Term Effects
Proton therapy treatment at California Protons Cancer Therapy Center in San Diego may offer similar outcomes to standard X-ray radiation, while reducing long-term and potentially life-threatening side effects such as heart attacks due to radiation damage to the heart. Proton therapy also offers the possibility of lower chances for secondary cancers later in life due to the reduced radiation exposure to your surrounding healthy tissues and organs.
However, all cancer treatments have advantages and disadvantages. Be sure to discuss all of the potential risks, as well as treatment options, with your oncologist.
Choosing the Right Path Forward
Deciding on lymphoma treatment is one of the most important health decisions you and your family will face. While traditional radiation remains effective, proton therapy offers unique advantages in precision, safety, and long-term quality of life — especially when vital organs like the heart and lungs are at risk.
At California Protons Cancer Therapy Center, our experienced team combines advanced pencil beam scanning technology with compassionate, patient-centered care. We work with every patient to design a personalized plan that balances effective treatment with preserving overall well-being.
If you or a loved one has been diagnosed with lymphoma, contact us today to schedule a consultation and learn whether proton therapy may be the right treatment option. With the right care and support, there is real hope for better outcomes and a healthier future.
Frequently Asked Questions
How effective is proton therapy for lymphoma?
Proton therapy is highly effective in treating many types of lymphoma. It provides the same tumor control as standard radiation but with fewer long-term risks, especially when tumors are near the heart, lungs, or breasts.
Is proton therapy effective for Hodgkin lymphoma?
Yes. Proton therapy for Hodgkin lymphoma is especially beneficial for patients whose tumors are located in the chest, near the heart, or lungs. Because it delivers radiation with precision, proton therapy can effectively treat the cancer while lowering the risk of long-term side effects such as heart disease or secondary cancers.
How long does proton therapy for lymphoma take?
Most patients undergo daily treatments, five days per week, for 4–6 weeks. Each session takes about 30–45 minutes, with actual proton delivery lasting only a few minutes.
What are the side effects of proton therapy for lymphoma?
Side effects are typically milder than with X-ray radiation. Patients may experience fatigue, mild skin irritation, or temporary hair loss at the treatment site. Most are able to continue daily activities throughout treatment.
Is proton therapy safe for children with lymphoma?
Yes. Proton therapy is often recommended for pediatric patients because it minimizes long-term risks to developing organs and reduces the likelihood of secondary cancers later in life.
Does insurance cover proton therapy for lymphoma?
Coverage varies depending on insurance provider and diagnosis. Our financial team works closely with patients and insurers to maximize coverage and minimize out-of-pocket costs.
Who should consider proton therapy for lymphoma?
Proton therapy may be most beneficial for patients whose lymphoma is located near critical organs such as the heart, lungs, or breasts. It is also an excellent option for younger patients and those who require re-treatment after prior radiation.
Can proton therapy cure lymphoma?
Proton therapy is not always considered a “cure” on its own, but it can be a highly effective part of a treatment plan. For many patients, it provides the same or better control rates as X-ray radiation while lowering risks of long-term complications.
What’s the difference between proton therapy and traditional radiation for lymphoma?
Traditional X-ray radiation passes through the body, depositing energy both before and after the tumor. Proton therapy, however, can stop precisely at the tumor site, reducing unnecessary radiation to nearby organs and lowering the risk of side effects.
How does proton therapy affect daily life during treatment?
Most lymphoma patients continue their normal routines, including work, exercise, and family activities, during proton therapy. Treatments are painless, and side effects are usually mild compared to traditional radiation.
Is proton therapy covered by Medicare or Medicaid?
Many Medicare plans and some state Medicaid programs provide coverage for proton therapy, especially for cancers where it has proven benefits, such as lymphomas near critical organs. Our financial team works with patients to explore all available coverage options.
What is the success rate of proton therapy for lymphoma?
Clinical outcomes vary depending on the type and stage of lymphoma, but studies show that proton therapy achieves high tumor control rates while significantly lowering long-term risks like secondary cancers and heart damage compared to standard radiation.